Brave Charlie Proctor needed a liver transplant after being diagnosed with a rare tumour in 2016.
His courageous fight against the disease captured the heart of the country – including US superstar Pink.
His parents Amber Schofield and Ben Proctor had launched an appeal to raise £855,580 for an operation for him in the US.
But at the weekend, Amber confirmed their son had taken his last breath.
The devastated mum, from Church, Accrington, Lancashire, posted a picture of Charlie with angel wings on Saturday night.
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Brave’s parents revealed sick son, 5, has only 336 hours left to live in heart-breaking Facebook post
Just hours earlier, she had posted a heart-breaking final photo of the youngster, saying he had told her: “Mummy I’m sorry for this.”
Amber wrote: “Last night at 23:14 my best friend, my world, Charlie, took his final breath.
“He fell asleep peacefully cuddled in my arms with daddy’s arms wrapped around us. Our hearts are aching. The world has lost an incredible little boy.
“Charlie, you gave me chance to be a mum. You have been, not only our biggest inspiration but you have been an inspiration to thousands of people all over the world.
“You showed me what love really means Charlie. Now it’s time to fly, I am so, so proud of you. You fought this so hard. My baby, I’m hurting so much. I will forever miss you baby bum. Sweet dreams my baby.”
“As the days go by he deteriorated more and more. He no longer looks like Charlie. He’s so thin; I can see and feel every bone in his tiny body, his sunken face, and his rolling eyes.
“Where has my chunky baby gone? Chunky from birth! He weighed 9’11lb! He’s was the cuddliest baby ever!
“He’s our chunk. I want everyone to remember Charlie for who he is. I want them to remember how he looked, how cheeky he was, how hilarious, how grumpy he was because right now Charlie isn’t any of those.
“He’s sad, he’s tired, he’s fed up and depressed. “I don’t know what to do anymore” are his main words. Today, he’s been very agitated, wanting to lie down, sit up, lay in bed, then on the beanbag, then on the sofa, then back upstairs and so on.
“Charlie, at one point, turned to me and said in the quietest, panting voice, ”Mummy, I’m so sorry for this” he was sorry because he wanted to move again and he felt he had to apologise for that?
“So now I know he also feels like he’s somewhat “in the way”. My heart broke! No child should feel the emotions Charlie is feeling. No Child! No parent should watch their child slowly go.
“Having to watch them deteriorate in this way is the most painful thing anyone will ever feel. If Charlie’s fate is to go, then I’d of rather the angels take him weeks ago before he suffered any more.
“His AFP is that high now that the machine can no longer read them. His liver function is the same apart from his Bilirubin, which has doubled causing Charlie’s skin colour to be yellow. After this, with every update, I will share photos of Charlie in his better days.
“How can I miss him so much when he’s led beside me? But I do. I miss him. I miss just having a chat, a cuddle that doesn’t cause pain. I miss squeezing him and kissing him all over.
“I miss his smile, knowing I won’t see that smile again other than in pictures, I will never hear Charlie laugh again???? Please pray for a miracle???????? Hold your babies tight and cuddle and kiss them so much.
“You don’t realise how lucky you are. We all take life for granted.
Last month, Charlie’s family were told he had just “two weeks, 366 hours” left to live.
Friends and family desperately tried to raise cash to send him to America for life-saving treatment, but last month announced it was to end.
Almost £360,000 had been pledged to help Charlie including a £10,000 donation from singer Pink and a £5,000 pledge from Pretty Little Thing founder Umar Kamani.
His family brought his sixth birthday forward by half a year so he could celebrate the milestone he wanted to reach.