Angry residents have set used tires ablaze as the death has become a rallying flag to demonstrate over poor roads in the mineral-rich town south of the region.
The teen was killed after a manganese-carrying truck from Ghana Manganese Company ran him over.
The violent protest comes barely two months after residents in Tarkwa blocked town roads, to prevent the travelling Lands and Natural Resources Minister, Kwaku Asomah Kyeremeh, from entering the town.
Photo: September 26, 2018 protests at Tarkwa
Backed by traditional leaders, the residents said they wanted to send an emphatic message to the government.
They have repeated the September 26 demonstration on November 16 as roads have been blocked.
A team of police officers are facing the protesters and tensions remain high.